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Mark Lawler Selected Research

CA 432

5/2011BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted ß-lactam analogue in human cancer cells.
11/2010The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.

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Mark Lawler Research Topics

Disease

43Neoplasms (Cancer)
11/2023 - 11/2005
21Colorectal Neoplasms (Colorectal Cancer)
03/2022 - 06/2014
13Prostatic Neoplasms (Prostate Cancer)
01/2022 - 08/2004
8Breast Neoplasms (Breast Cancer)
01/2021 - 11/2005
5Hypoxia (Hypoxemia)
10/2020 - 01/2009
5BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
12/2015 - 05/2002
4Lung Neoplasms (Lung Cancer)
03/2023 - 01/2015
4Colonic Neoplasms (Colon Cancer)
12/2022 - 06/2016
4Polyploidy
05/2011 - 04/2007
4Carcinoma (Carcinomatosis)
05/2011 - 11/2005
3Neoplasm Metastasis (Metastasis)
12/2022 - 11/2016
3Leukemia
11/2010 - 09/2004
2COVID-19
08/2023 - 01/2022
2Inflammation (Inflammations)
01/2023 - 01/2021
2Microsatellite Instability
01/2021 - 01/2016
2Disease Progression
10/2020 - 12/2015
2Rectal Neoplasms (Rectal Cancer)
01/2018 - 01/2017
2Melanoma (Melanoma, Malignant)
12/2015 - 01/2015
2Aplastic Anemia (Anemia, Hypoplastic)
03/2009 - 12/2004
1Skin Neoplasms (Skin Cancer)
02/2024
1Squamous Cell Neoplasms (Squamous Cell Cancer)
01/2023
1Squamous Cell Carcinoma of Head and Neck
01/2023
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2021
1Esophageal Neoplasms (Esophageal Cancer)
01/2021
1Phototoxic Dermatitis (Phototoxicity)
08/2020
1Neuroblastoma
07/2019
1Pancreatic Neoplasms (Pancreatic Cancer)
11/2018
1Frailty
11/2018
1Ataxia (Dyssynergia)
01/2018
1Chronic Obstructive Pulmonary Disease (COPD)
03/2017
1Intestinal Neoplasms (Intestinal Cancer)
01/2017
1Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/2017

Drug/Important Bio-Agent (IBA)

17Biomarkers (Surrogate Marker)IBA
01/2023 - 09/2004
11Proteins (Proteins, Gene)FDA Link
01/2021 - 06/2005
6DNA (Deoxyribonucleic Acid)IBA
01/2023 - 02/2008
6PBOX-6IBA
12/2010 - 09/2004
5RNA (Ribonucleic Acid)IBA
01/2022 - 08/2016
4Immune Checkpoint InhibitorsIBA
01/2023 - 01/2016
4TubulinIBA
05/2011 - 02/2008
3Messenger RNA (mRNA)IBA
10/2020 - 06/2005
3Caspase 3 (Caspase-3)IBA
03/2017 - 01/2010
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2017 - 06/2014
3Imatinib Mesylate (Gleevec)FDA Link
01/2016 - 04/2007
34- acetoxy- 5- (1- (naphthyl))naphtho(2,3- b)pyrrolo(2,1- d)(1,4)oxazepineIBA
02/2011 - 04/2008
3Hormones (Hormone)IBA
12/2010 - 11/2005
2insulin receptor-related receptor (IRR)IBA
08/2023 - 01/2023
2PlatinumIBA
01/2023 - 01/2021
2Calcibiotic Root Canal SealerIBA
03/2022 - 10/2020
2CaspasesIBA
01/2022 - 01/2021
2ChemokinesIBA
01/2021 - 06/2016
2Fluorouracil (Carac)FDA LinkGeneric
01/2021 - 02/2009
2LigandsIBA
08/2020 - 11/2016
2Estrogen ReceptorsIBA
01/2019 - 11/2005
2Small Interfering RNA (siRNA)IBA
07/2015 - 05/2011
2EnzymesIBA
12/2011 - 02/2009
2CA 432IBA
05/2011 - 11/2010
2LactamsIBA
05/2011 - 11/2010
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
02/2009 - 01/2009
2Phosphotransferases (Kinase)IBA
04/2007 - 09/2004
1A-factor (Streptomyces)IBA
11/2023
1Analgesics (Analgesic Drugs)IBA
08/2023
1Opioid Analgesics (Opioids)IBA
08/2023
1Poly I-CIBA
12/2022
1Cetuximab (Erbitux)FDA Link
01/2022
1Tumor Biomarkers (Tumor Markers)IBA
01/2022
1DAPIIBA
01/2022
1Complement System Proteins (Complement)IBA
01/2022
1Keratins (Keratin)IBA
01/2022
11-phenyl-3,3-dimethyltriazene (PDT)IBA
10/2021
1Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2021
1Caspase 10IBA
01/2021
1Caspase 8 (Caspase-8)IBA
01/2021
1Histone Deacetylases (Histone Deacetylase)IBA
01/2021
13- (2- (2- tert- butylphenylaminooxalyl)aminopropionylamino)- 4- oxo- 5- (2,3,5,6- tetrafluorophenoxy)pentanoic acidIBA
01/2021
1ASTX-660IBA
01/2021
1MetalsIBA
08/2020
1Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
07/2019
1Glycoproteins (Glycoprotein)IBA
07/2019
1ElementsIBA
11/2018
1bcl-X ProteinIBA
01/2018
1Caspase 9IBA
03/2017
1ParaffinIBA
01/2017
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
01/2017
1Formaldehyde (Formol)FDA Link
01/2017
1Proto-Oncogene Proteins c-metIBA
01/2017
1B7-H1 AntigenIBA
01/2016
1Histone Deacetylase InhibitorsIBA
07/2015
1Trastuzumab (Herceptin)FDA Link
01/2015
1hydrogen sulfite (bisulfite)IBA
10/2012

Therapy/Procedure

17Therapeutics
07/2023 - 03/2004
9Drug Therapy (Chemotherapy)
02/2024 - 07/2006
7Precision Medicine
10/2021 - 01/2015
4Adjuvant Chemotherapy
12/2022 - 01/2016
2Radiotherapy
01/2023 - 12/2011
2Lasers (Laser)
01/2022 - 01/2018
2Palliative Care (Palliative Therapy)
01/2021 - 11/2018
1Length of Stay
03/2023
1Patient Care
01/2021
1Chemoradiotherapy
01/2017
1Immunotherapy
01/2016